Oromaxillofacial manifestations of COVID-19
Keywords:
Breast Cancer, Risk Factors, NeoplasiaAbstract
Studies have reported that COVID-19 infected patients can present oraland maxillofacial manifestations with multiple clinical aspects.A
bibliographic search was carried out in the Infomed, PubMed and SciELO
databases which aim was to describe the main oral and maxillofacial
manifestations related to COVID-19. As a result, 24 articles were selected
according to their significance to the subject. The impact of COVID-19 on
orofacial structures is mainly determine by the patient’s immune system,
the drug therapy administered and the pathogenesis of the virus. The
heterogeneity and prevalence of these manifestations have determined
the necessity of carrying out routine oral examinations by specialists in
Stomatology, as part of the multidisciplinary approach required for the
success of the treatment.
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References
1- Pastrian G. Bases Genéticas y Moleculares del COVID-19 (SARS-CoV-2). Mecanismos de Patogénesis y de Respuesta Inmune. Int. J. Odontostomat. [Internet]. 2020 [citado 2021 Abr 24]; 97: 326–328. Disponible en: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2020000300331&Ing=es
2- La Rosa GRM, Libra M, De Pasquale R, Ferlito S, Pedullà E. Association of Viral Infections with Oral Cavity Lesions: Role of SARS-CoV-2 Infection. Front. Med. [Internet]. 2021 [citado 2021 Abr 24]; 7(571214): 141-154. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840611/
3- Santos JA, Costa AG, Carvalho RL, Monteiro R, Cembranel AC, Santos AR, et al. Oral mucosal lesions in a COVID-19 patient: New signs or secondary manifestations? International Journal of Infectious Diseases [Internet]. 2020 [citado 2021 Abr 24]; 97: 326–328. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280113/
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5- Pedrosa MS, Sipert CR, Nogueira FN. Salivary glands, saliva and oral findings in COVID-19 infection. Pesqui Bras Odontopediatria Clín Integr. [Internet]. 2020 [citado 2021 Abr 24]; 20(supp1): e0104. Disponible en: https://doi.org/10.1590/pboci.2020.112
6- Velázquez RI. Historia de las infecciones por coronavirus y epidemiología de la infección por SARS-CoV-2. Rev. Mex Traspl. [Internet]. 2020 [citado 2021 Abr 24]; 9(S2): s149-s159. Disponible en: https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=94504
7- Infomed [Internet]. La Habana, Cuba: Izquierdo T. 1992 [actualizado 2021 Sep 7; citado 2021 Abr 24]. Disponible en: https://temas.sld.cu/coronavirus/covid-19/
8- Llerena VY, Toledo BF, Fimia R, Aguilera Y, Carmona M. Gingivoestomatitis Estreptocócica en tiempo de COVID-19. The Biologist (Lima). [Internet]. 2021 [citado 2021 Abr 24]; 19 (1), 125-129. Disponible en: https://revistas.unfv.edu.pe/rtb/article/view/890/785
9- Nemeth-Kohanszky ME, Matus-Abásolo CP, Carrasco-Soto RR. Manifestaciones Orales de la Infección por COVID-19. Int. J. Odontostomat. [Internet]. 2020 [citado 2021 Abr 24]; 14(4):555-560. Disponible en: https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2020000400555&lang=pt
10- Gherlone E.F, Polizzi E, Tetè G, De Lorenzo R, Magnaghi C, Rovere Querini P, et al. Frequent and Persistent Salivary Gland Ectasia and Oral Disease After COVID-19. Journal of Dental Res. [Internet]. 2021 [citado 2021 Abr 24]; 100(5): 464-471. Disponible en: https://doi.org/10.1177/0022034521997112
11- Parra EA, Bermúdez M, Peña CP, Rueda A. Manifestaciones orales y maxilofaciales asociadas a la COVID-19. Revisión de la literatura. Acta Odont. Col. [Internet]. 2020 [citado 2021 Abr 24]; 10 (Supl. COVID-19): 60-80. Disponible en: https://www.researchgate.net/publication/347568400_Manifestaciones_orales_y_maxilofaciales_asociadas_a_la_COVID-19_Revision_de_la_literatura_Oral_and_maxillofacial_manifestations_associated_with_COVID-19_Literature_review
12- Halboub E, Al-Maweri SA, Alanazi RH, Qaid NM, Abdulrab S. Orofacial manifestations of COVID-19: a brief review of the published literature. Braz Oral Res. [Internet]. 2020 [citado 2021 Abr 24]; 34: e124. Disponible en: https://www.scielo.br/j/bor/a/DRqH7Qp4RPm6XbCT7Y4mfZN/?lang=en
13- Favia G, Tempesta A, Barile G, Brienza N, Capodiferro S, Vestito MC, et al. Covid-19 Symptomatic Patients with Oral Lesions: Clinical and Histopathological Study on 123 Cases of the University Hospital Policlinic of Bari with a Purpose of a New Classification. J. Clin. Med. [Internet]. 2021 [citado 2021 Abr 24]; 10(757): 1-10. Disponible en: https://www.mdpi.com/2077-0383/10/4/757/htm
14- Amorim dos Santos J, Normando AGC, Carvalho da Silva RL, Acevedo AC, De Luca Canto G, Sugaya N, et al. Oral Manifestations in Patients with COVID-19: A Living Systematic Review. Journal of Dental Research. [Internet]. 2021 [citado 2021 Abr 24]; 100(2): 141-154. Disponible en: https://doi.org/10.1177/0022034520957289
15- Hocková B, Riad A, Valky J, Šulajová Z, Stebel A, Slávik R, et al. Oral Complications of ICU Patients with COVID-19: Case-Series and Review of Two Hundred Ten Cases. J. Clin. Med. [Internet]. 2021 [citado 2021 Abr 24]; 10(581): 1-14. Disponible en: https://www.mdpi.com/2077-0383/10/4/581/htm
16- Brandao TB, Gueiros LA, Melo TS, Prado-Ribeiro AC, Nesrallah ACFA, Prado GVB, et al. Oral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a target organ? Oral Surg Oral Med Oral Pathol Oral Radiol. [Internet]. 2021 [citado 2021 Abr 24]; 131(2): e45-e51. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434495/
17- Tsuchiya H. Oral Symptoms Associated with COVID-19 and Their Pathogenic Mechanisms: A Literature Review. Dent. J. [Internet]. 2021 [citado 2021 Abr 24]; 9(32): 1-28. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999671/
18- Brandini DA, Takamiya AS, Thakkar P, Schaller S, Rahat R, Naqvi AR. Covid‐19 and oral diseases: Crosstalk, synergy or association? Rev Med Virol. [Internet]. 2021 [citado 2021 Abr 24]; 1-15 p. Disponible en: https://onlinelibrary.wiley.com/doi/10.1002/rmv.2226
19- Biadsee A, Kassem F, Dagan O, Masarwa S, Ormianer Z. Olfactory and Oral Manifestations of COVID-19: Sex-Related Symptoms-A potential pathway to early diagnosis. Otolaryngol Head Neck Surg. [Internet]. 2020 [citado 2021 Abr 24]; 163(4): 722-728. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298562/
20- Gutiérrez R, Zambrano G. Implicaciones bucales por COVID-19. Revisión de tema. Odontol. Sanmarquina. [Internet]. 2020 [citado 2021 Abr 24]; 23(4): 419-423. Disponible en: https://revistasinvestigacion.unmsm.edu.pe/index.php/odont/article/view/19104/15996
21- Vaira LA, Deiana G, Fois AG, Pirina P, Madeddu G, De Vito A, et al. Objective evaluation of anosmia and ageusia in COVID-19 patients: Single-center experience on 72 cases. Head Neck. [Internet]. 2020 [citado 2021 Abr 24]; 42(6): 1252-1258. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1002/hed.26204
22- Romero CA, López MA, Anaya DA, Flores SS, Mendoza V, Martínez J, et al. Alteraciones del gusto y el olfato en el contexto de la pandemia por SARS-CoV-2. Análisis preliminar. An Orl Mex. [Internet]. 2020 [citado 2021 Abr 24]; 65(3): 147-155. Disponible en: https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=96289
23- Emodi A, Eli I, Smardz J, Uziel N, Wieckiewicz M. Temporomandibular Disorders and Bruxism Outbreak as a Possible Factor of Orofacial Pain Worsening during the COVID-19 Pandemic-Concomitant Research in Two Countries. J Clin Med. [Internet]. 2020 [citado 2021 Abr 24];9(10): 3250. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601612/
24- Almeida Leite CM, Stuginski Barbosa J, Rodrigues Conti PC. How psychosocial and economic impacts of COVID-19 pandemic can interfere on bruxism and temporomandibular disorders? J Appl Oral Sci [Internet]. 2020 [citado 2021 Abr 24]; 28: e20200263. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213779/
2- La Rosa GRM, Libra M, De Pasquale R, Ferlito S, Pedullà E. Association of Viral Infections with Oral Cavity Lesions: Role of SARS-CoV-2 Infection. Front. Med. [Internet]. 2021 [citado 2021 Abr 24]; 7(571214): 141-154. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840611/
3- Santos JA, Costa AG, Carvalho RL, Monteiro R, Cembranel AC, Santos AR, et al. Oral mucosal lesions in a COVID-19 patient: New signs or secondary manifestations? International Journal of Infectious Diseases [Internet]. 2020 [citado 2021 Abr 24]; 97: 326–328. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280113/
4- Egido-Moreno S, Valls-Roca-Umbert J, Jané-Salas E, López-López J, Estrugo-Devesa A. COVID-19 and oral lesions, short communication and review. J Clin Exp Dent. [Internet]. 2021 [citado 2021 Abr 24]; 13(3): e287-e294. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920556/
5- Pedrosa MS, Sipert CR, Nogueira FN. Salivary glands, saliva and oral findings in COVID-19 infection. Pesqui Bras Odontopediatria Clín Integr. [Internet]. 2020 [citado 2021 Abr 24]; 20(supp1): e0104. Disponible en: https://doi.org/10.1590/pboci.2020.112
6- Velázquez RI. Historia de las infecciones por coronavirus y epidemiología de la infección por SARS-CoV-2. Rev. Mex Traspl. [Internet]. 2020 [citado 2021 Abr 24]; 9(S2): s149-s159. Disponible en: https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=94504
7- Infomed [Internet]. La Habana, Cuba: Izquierdo T. 1992 [actualizado 2021 Sep 7; citado 2021 Abr 24]. Disponible en: https://temas.sld.cu/coronavirus/covid-19/
8- Llerena VY, Toledo BF, Fimia R, Aguilera Y, Carmona M. Gingivoestomatitis Estreptocócica en tiempo de COVID-19. The Biologist (Lima). [Internet]. 2021 [citado 2021 Abr 24]; 19 (1), 125-129. Disponible en: https://revistas.unfv.edu.pe/rtb/article/view/890/785
9- Nemeth-Kohanszky ME, Matus-Abásolo CP, Carrasco-Soto RR. Manifestaciones Orales de la Infección por COVID-19. Int. J. Odontostomat. [Internet]. 2020 [citado 2021 Abr 24]; 14(4):555-560. Disponible en: https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2020000400555&lang=pt
10- Gherlone E.F, Polizzi E, Tetè G, De Lorenzo R, Magnaghi C, Rovere Querini P, et al. Frequent and Persistent Salivary Gland Ectasia and Oral Disease After COVID-19. Journal of Dental Res. [Internet]. 2021 [citado 2021 Abr 24]; 100(5): 464-471. Disponible en: https://doi.org/10.1177/0022034521997112
11- Parra EA, Bermúdez M, Peña CP, Rueda A. Manifestaciones orales y maxilofaciales asociadas a la COVID-19. Revisión de la literatura. Acta Odont. Col. [Internet]. 2020 [citado 2021 Abr 24]; 10 (Supl. COVID-19): 60-80. Disponible en: https://www.researchgate.net/publication/347568400_Manifestaciones_orales_y_maxilofaciales_asociadas_a_la_COVID-19_Revision_de_la_literatura_Oral_and_maxillofacial_manifestations_associated_with_COVID-19_Literature_review
12- Halboub E, Al-Maweri SA, Alanazi RH, Qaid NM, Abdulrab S. Orofacial manifestations of COVID-19: a brief review of the published literature. Braz Oral Res. [Internet]. 2020 [citado 2021 Abr 24]; 34: e124. Disponible en: https://www.scielo.br/j/bor/a/DRqH7Qp4RPm6XbCT7Y4mfZN/?lang=en
13- Favia G, Tempesta A, Barile G, Brienza N, Capodiferro S, Vestito MC, et al. Covid-19 Symptomatic Patients with Oral Lesions: Clinical and Histopathological Study on 123 Cases of the University Hospital Policlinic of Bari with a Purpose of a New Classification. J. Clin. Med. [Internet]. 2021 [citado 2021 Abr 24]; 10(757): 1-10. Disponible en: https://www.mdpi.com/2077-0383/10/4/757/htm
14- Amorim dos Santos J, Normando AGC, Carvalho da Silva RL, Acevedo AC, De Luca Canto G, Sugaya N, et al. Oral Manifestations in Patients with COVID-19: A Living Systematic Review. Journal of Dental Research. [Internet]. 2021 [citado 2021 Abr 24]; 100(2): 141-154. Disponible en: https://doi.org/10.1177/0022034520957289
15- Hocková B, Riad A, Valky J, Šulajová Z, Stebel A, Slávik R, et al. Oral Complications of ICU Patients with COVID-19: Case-Series and Review of Two Hundred Ten Cases. J. Clin. Med. [Internet]. 2021 [citado 2021 Abr 24]; 10(581): 1-14. Disponible en: https://www.mdpi.com/2077-0383/10/4/581/htm
16- Brandao TB, Gueiros LA, Melo TS, Prado-Ribeiro AC, Nesrallah ACFA, Prado GVB, et al. Oral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a target organ? Oral Surg Oral Med Oral Pathol Oral Radiol. [Internet]. 2021 [citado 2021 Abr 24]; 131(2): e45-e51. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434495/
17- Tsuchiya H. Oral Symptoms Associated with COVID-19 and Their Pathogenic Mechanisms: A Literature Review. Dent. J. [Internet]. 2021 [citado 2021 Abr 24]; 9(32): 1-28. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999671/
18- Brandini DA, Takamiya AS, Thakkar P, Schaller S, Rahat R, Naqvi AR. Covid‐19 and oral diseases: Crosstalk, synergy or association? Rev Med Virol. [Internet]. 2021 [citado 2021 Abr 24]; 1-15 p. Disponible en: https://onlinelibrary.wiley.com/doi/10.1002/rmv.2226
19- Biadsee A, Kassem F, Dagan O, Masarwa S, Ormianer Z. Olfactory and Oral Manifestations of COVID-19: Sex-Related Symptoms-A potential pathway to early diagnosis. Otolaryngol Head Neck Surg. [Internet]. 2020 [citado 2021 Abr 24]; 163(4): 722-728. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298562/
20- Gutiérrez R, Zambrano G. Implicaciones bucales por COVID-19. Revisión de tema. Odontol. Sanmarquina. [Internet]. 2020 [citado 2021 Abr 24]; 23(4): 419-423. Disponible en: https://revistasinvestigacion.unmsm.edu.pe/index.php/odont/article/view/19104/15996
21- Vaira LA, Deiana G, Fois AG, Pirina P, Madeddu G, De Vito A, et al. Objective evaluation of anosmia and ageusia in COVID-19 patients: Single-center experience on 72 cases. Head Neck. [Internet]. 2020 [citado 2021 Abr 24]; 42(6): 1252-1258. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1002/hed.26204
22- Romero CA, López MA, Anaya DA, Flores SS, Mendoza V, Martínez J, et al. Alteraciones del gusto y el olfato en el contexto de la pandemia por SARS-CoV-2. Análisis preliminar. An Orl Mex. [Internet]. 2020 [citado 2021 Abr 24]; 65(3): 147-155. Disponible en: https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=96289
23- Emodi A, Eli I, Smardz J, Uziel N, Wieckiewicz M. Temporomandibular Disorders and Bruxism Outbreak as a Possible Factor of Orofacial Pain Worsening during the COVID-19 Pandemic-Concomitant Research in Two Countries. J Clin Med. [Internet]. 2020 [citado 2021 Abr 24];9(10): 3250. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601612/
24- Almeida Leite CM, Stuginski Barbosa J, Rodrigues Conti PC. How psychosocial and economic impacts of COVID-19 pandemic can interfere on bruxism and temporomandibular disorders? J Appl Oral Sci [Internet]. 2020 [citado 2021 Abr 24]; 28: e20200263. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213779/
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2022-02-06
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Leyva-Pupo IV, Hierrezuelo-Fuentes L, Leyva-Pupo LV, Yllodo-Cristo A. Oromaxillofacial manifestations of COVID-19. MedEst [Internet]. 2022 Feb. 6 [cited 2024 Dec. 4];1(2):e77. Available from: https://revmedest.sld.cu/index.php/medest/article/view/77
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