Update on cholesterol metabolism and its influence on atherosclerosis

Authors

Keywords:

Atherosclerosis, Cholesterol, Metabolism, Prevention

Abstract

Introduction: Atherosclerosis is a disease that begins at the molecular level with metabolism - cholesterol and is the cause of several ailments, including cardiovascular and cerebrovascular diseases, responsible for high morbidity and mortality worldwide. Currently, the best way to prevent this disease is to control unhealthy lifestyles.

Objective: to provide an update on cholesterol metabolism, highlighting its influence on atherosclerosis.

Method: a bibliographic review was carried out using reference books, printed articles, journals and the PubMed, EBSCO, HINARI, LILACS and CUMED databases, searching up to the year 2022 in English and Spanish. Finally, 21 references were consulted.

Development: atherosclerotic lesions occur in the arterial intima and, according to their severity, are divided in ascending order into: fatty streaks, fibrous plaques and severe plaques. Its pathogenesis is associated with endothelial lesions and is closely related to multiple risk factors. The atherometric system of José E. Fernández-Britto Rodríguez and researchers from the Higher Institute of Medical Sciences of Havana, has made it possible to measure arterial lesions in different sectors in deceased patients.

Conclusions: cholesterol metabolism shows the fundamental cause of an unhealthy lifestyle causing atherosclerosis, which in turn brings health problems that occupy a place among the first causes of death worldwide, which is why its exhaustive study is necessary, applying the atherometric system, which is irreplaceable to this day for its prevention.

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References

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Published

2023-04-30

How to Cite

1.
Pérez-Alvarez A, Gálvez-Vila RM, Ruiz-Reyes D, Ordóñez-Smith Y. Update on cholesterol metabolism and its influence on atherosclerosis. MedEst [Internet]. 2023 Apr. 30 [cited 2024 Dec. 4];3(1):e235. Available from: https://revmedest.sld.cu/index.php/medest/article/view/235

Issue

Vol. 3 No. 1 (2023)

Section

REVIEW ARTICLES

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