Acute generalized exanthematous pustulosis due to paracetamol: a case report
Keywords:
Acute Generalized Exanthematous Pustulosis, ParacetamolAbstract
Introduction: Acute Generalized Exanthematous Pustulosis is a rare and severe cutaneous adverse reaction, primarily induced by drugs, and classified as a severe cutaneous adverse reaction. It is characterized by the sudden appearance of non-follicular, sterile pustules on an erythematous and edematous base, accompanied by fever and leukocytosis with neutrophilia.
Objective: To report a typical case of Acute Generalized Exanthematous Pustulosis due to paracetamol, confirmed using standardized diagnostic criteria.
Case presentation: We present the case of a 24-year-old male patient with Acute Generalized Exanthematous Pustulosis triggered by paracetamol. The typical clinical presentation of fever and non-follicular pustules on an erythematous base, along with compatible histopathology and a score of 11 on the European Study of Severe Cutaneous Adverse Reactions scale, confirmed the diagnosis. Management consisted of immediate discontinuation of the drug and systemic corticosteroids, with complete resolution within 3 weeks.
Conclusions: This case exemplifies that paracetamol, a commonly used medication, can induce severe skin reactions. It demonstrates the usefulness of validated scoring systems for accurate diagnosis. It reaffirms the importance of a thorough drug history in dermatology. The favorable outcome underscores that the cornerstone of treatment is the identification and withdrawal of the causative agent.
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