Advanced mandibular ameloblastoma: a case report

Authors

Keywords:

Ameloblastoma, Maxillofacial Surgery, Oral neoplasms

Abstract

Introduction: ameloblastoma is the most frequent benign epithelial odontogenic tumor, characterized by slow growth, high recurrence rate, and extensive bone destruction capacity. Delayed diagnosis results in large lesions with functional compromise and severe facial deformities.

Objective: to describe a case of advanced mandibular ameloblastoma in a geriatric patient, emphasizing the implications of delayed diagnosis in surgical management.

Case presentation: 78-year-old male patient with progressive volume increase in left hemiface and neck of 10 years evolution. Presented mechanical dysphagia, dysarthria, and recurrent oral bleeding. Physical examination revealed 10 cm diameter tumor, stony consistency, without inflammatory signs. Computed tomography showed multilocular osteolytic lesion of 7.2 × 9.9 cm occupying body and ascending ramus of left hemimandible, with destruction of more than 50% of bone. Incisional biopsy confirmed ameloblastoma. Radical hemimandibulectomy with disarticulation and safety margins was performed under general anesthesia. Definitive histopathological study confirmed follicular ameloblastoma. Postoperative evolution was satisfactory, without complications, discharged on tenth day.

Conclusions: delayed diagnosis of ameloblastoma in geriatric patients determines the need for extensive surgical resections with greater morbidity. This case underscores the importance of systematic oral examination in routine stomatological practice for early detection of odontogenic lesions.

Downloads

Download data is not yet available.

References

1. Hernández Gálvez Y, Ducasse Olivera PA, Abull Jauregui J. Ameloblastoma mandibular: resultados del tratamiento quirúrgico. AACC [Internet]. 2021 [citado 19/09/2025];11(1). Disponible en: https://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S230401062021000100022&lng=es&tlng=es

2. Rabelo CA. Ameloblastoma mandibular convencional en etapa avanzada. CCM [Internet]. 2022 [citado 19/09/2025];26(1):218-26. Disponible en: https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=113261

3. Soriano Cueto Y, Reyna Villasmil E. Ameloblastoma unquístico de mandíbula. RRMC [Internet]. 2023 [citado 19/09/2025];32(2). Disponible en: https://revistas.facusalud.edu.co/index.php/repertorio/article/view/1251/2459

4. Troya BE, Batista VM, Díaz DD. Hemimandibulectomía por ameloblastoma multiquístico. A propósito de un caso. RME [Internet]. 2021 [citado 19/09/2025];43(2). Disponible en: https://scielo.sld.cu/scielo.php?pid=S1684-18242021000203239&script=sci_abstract&tlng=en

5. Mendoza Álvarez S, Alonso Moctezuma A, Salgado Chavarría F. Ameloblastoma: historia y patogénesis molecular actual. RMCBM [Internet]. 2024 [citado 19/09/2025];20(1). Disponible en: https://www.medigraphic.com/pdfs/cirugiabucal/cb-2024/cb241f.pdf

6. Sánchez JG, Hernández FO, Hernández DY. Reemplazo mandibular con prótesis personalizada de titanio posterior a la exéresis de ameloblastoma. RCE [Internet]. 2021 [citado 19/09/2025];58(3). Disponible en: https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=109788

7. Suhani G. Ameloblastoma: una revisión narrativa actualizada de un tumor enigmático. Cureus [Internet]. 2022 [citado 19/09/2025];14(8):e27734. Disponible en: https://assets.cureus.com/uploads/review_article/pdf/108348/20220916-25113-8tjhft.pdf

8. Decani S, Quatrale M, Caria V, Moneghini L, Varoni EM. Peripheral Ameloblastoma: A Case Report and Review of Literature. JCM. 2024;13(22):6714. DOI:10.3390/jcm13226714

9. Hu K, Zhang X, Chen R, Li X. Recent methods for the diagnosis and differentiation of ameloblastoma: a narrative review. TF. 2024;17(1). DOI:10.1080/26895293.2024.2354675

10. Cardoso LB, Lopes IA, Ikuta CRS, Capelozza ALA. Study between panoramic radiography and cone beam-computed tomography in the diagnosis of ameloblastoma, odontogenic keratocyst, and dentigerous cyst. J Craniofac Surg. 2020;31(6):1747-52. DOI:10.1097/SCS.0000000000006538

11. Ajilay V, Hegde S. Ameloblastomas vs recurrent ameloblastomas: a systematic review. JOMOS [Internet]. 2022 [citado 20/09/2025];28(1). Disponible en: https://www.jomos.org/articles/mbcb/full_html/2022/01/mbcb210101/mbcb210101.html

12. Hashemi H, Näsman A, Farzad P. Peripheral ameloblastoma presenting as a solid mass in the temporal fossa: A case report and review of the literature. OMSC [Internet]. 2022 [citado 20/09/2025];8(4). Disponible en: https://www.sciencedirect.com/science/article/pii/S2214541922000438

13. Chai ZK, Mao L, Chen H, Sun TG, Shen XM, Liu J, Sun ZJ. Improved diagnostic accuracy of ameloblastoma and odontogenic keratocyst on cone-beam CT by artificial intelligence. Front Oncol. 2021;11:793417. DOI:10.3389/fonc.2021.793417

14. García Cruz CA, Soler Izquierdo E, Niño Peña A, Batista Marrero K. Ameloblastoma unquístico plexiforme de maxilar superior. A propósito de un caso. CCM [Internet]. 2022 [citado 21/09/2025];26(4). Disponible en: https://revcocmed.sld.cu/index.php/cocmed/article/view/4513/2218

15. Delarue M, Derruau S, Troyon P, Bogard F, Polidori G, Mauprivez C. Medical infrared thermography in peri-operative management of peripheral ameloblastoma: A case report. Photodiagnosis Photodyn Ther. 2021;34:102167. DOI:10.1016/j.pdpdt.2020.102167

Published

2026-02-22

How to Cite

1.
Pérez-Pagés PA, Lima-Reyna MT, Espino-Hernández EG, Perera-Cadavieco E. Advanced mandibular ameloblastoma: a case report. MedEst [Internet]. 2026 Feb. 22 [cited 2026 Feb. 28];6:e485. Available from: https://revmedest.sld.cu/index.php/medest/article/view/485

Issue

Section

CASE PRESENTATION