Integration of medicinal plants in post-COVID-19 family and community integrative rehabilitation

Abstract

Post-COVID-19 syndrome presents a chronic health challenge characterized by a desynchronization of biological rhythms, perpetuating inflammation and systemic dysfunction. In response to this problem, this opinion piece proposes an integrative family and community rehabilitation approach, based on the SEN project, which transcends the traditional biomedical model to focus on restoring homeostasis. The presented paradigm views medicinal plants as natural metabolic signalers and epigenetic modulators, capable of resynchronizing the body in its various chronobiological states: wakefulness, sleep, sunset, feeding, and fasting. Scientific evidence supports the use of bioactive compounds such as polyphenols, flavonoids, and terpenes—present in plants like turmeric, gotu kola, and mulberry—due to their ability to regulate gene expression, inhibit pro-inflammatory pathways, and reduce oxidative damage, effects that are fundamental for managing post-infectious sequelae. A key aspect of this work is its translational nature, outlining a concrete path that links scientific knowledge, local production of phytopharmaceuticals, and a personalized care plan, articulated through an intersectoral network integrating academic, healthcare, and community institutions. In short, the article offers a transdisciplinary vision that transforms complex concepts from chronobiology and epigenetics into practical tools for self-care, providing a viable way to restore the balance lost in the post-pandemic era.