Clinical characterization of patients with cervical cancer at the Provincial Gynecological-Obstetrical Hospital. Matanzas, 2023-2025

Authors

Keywords:

Cervical Cancer; Risk Factors; Prevention; Neoplasm Staging; Cuba

Abstract

Introduction: Cervical cancer (CC) is one of the leading causes of female mortality worldwide, with a high incidence in developing countries. In Cuba, it represents a significant health problem.

Objective: To characterize patients diagnosed with CC treated at the "José Ramón López Tabrane" Provincial Teaching Gynecological and Obstetrical Hospital in Matanzas between January 2023 and December 2025.

Methods: Observational, descriptive, cross‑sectional study. Eighty‑eight patients with histopathologically confirmed diagnosis were included. Sociodemographic variables, risk factors, obstetric history, sexual behavior, clinical stage, histological type, and screening history were analyzed. Descriptive statistics and chi‑square tests were used to explore associations.

Results: The predominant age group was 36‑40 years (28.4%), housewives (52.3%), single (61.4%), pre‑university education (56.8%), smokers (58.0%), Black (44.3%), and multiparous (43.2%). Sexual debut between 14‑19 years occurred in 60.2% and 3‑4 partners in 40.9%. Squamous cell carcinoma was the most frequent (67.0%) and stage II the predominant (38.6%). 67.0% had no screening in the last 3 years. Smoking (p=0.041) and multiparity (p=0.032) were significantly associated with more advanced stages.

Conclusions: The patient profile matches classical risk factors. The association between smoking, multiparity, and advanced stages, together with low screening coverage, reinforces the need to strengthen screening and preventive interventions in the province.

Downloads

Download data is not yet available.

References

1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209 49. doi:10.3322/caac.21660

2. Singh D, Vignat J, Lorenzoni V, et al. Global estimates of incidence and mortality of cervical cancer in 2020: a baseline analysis of the WHO Global Cervical Cancer Elimination Initiative. Lancet Glob Health. 2023;11(2):e197-e206. doi:10.1016/S2214-109X(22)00501-0

3. Liu Y, Ai H. Comprehensive insights into human papillomavirus and cervical cancer: Pathophysiology, screening, and vaccination strategies. Biochim Biophys Acta Rev Cancer. 2024;1879(6):189192. doi:10.1016/j.bbcan.2024.189192

4. World Health Organization. Global strategy to accelerate the elimination of cervical cancer as a public health problem. Geneva: WHO; [Internet] 2020 [citado 24/11/2025]. Disponible en: https://www.who.int/publications/i/item/9789240014107

5. Muñoz N, Franceschi S, Bosetti C, Moreno V, Herrero R, Smith JS, et al. Role of parity and human papillomavirus in cervical cancer: the IARC multicentric case control study. Lancet. 2002;359(9312):1093 101. doi:10.1016/S0140-6736(02)08151-5

6. Ministerio de Salud Pública (MINSAP). Anuario Estadístico de Salud 2024. La Habana: MINSAP; [Internet] 2025 [citado 24/11/2025]. Disponible en: https://files.sld.cu/bvscuba/files/2025/05/Anuario-Estadistico-de-Salud-2024.pdf

7. Figueredo Fonseca M, Fernández Núñez D, Hidalgo Rodríguez M, Rodríguez Reúna R, Álvarez Paneque T. Intervención educativa sobre cáncer cervicouterino. Multimed. [Internet] 2021 [citado 24/11/2025];23(4). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-48182019000400731

8. Bhatla N, Aoki D, Sharma DN, Sankaranarayanan R. Cancer of the cervix uteri: 2021 update. Int J Gynaecol Obstet. 2021;155(Suppl 1):28 44. doi:10.1002/ijgo.13865

9. Hermida Lazcano I. Caracterización de mujeres con diagnóstico de cáncer cervicouterino. Rev Cuba Obstet Ginecol. [Internet] 2021 [citado 24/11/2025];47(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0138-600X2021000200007

10. Palma Osorio M, Romero Flores AD, Torres Mesa AI. Factores de riesgo en las lesiones intraepiteliales del cuello uterino. Rev Finlay. [Internet] 2019 [citado 24/11/2025];9(4). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S2221-24342019000400291

11. Castellsagué X. Natural history and epidemiology of HPV infection and cervical cancer. Gynecol Oncol. 2008;110(3 Suppl 2):S4 7. doi:10.1016/j.ygyno.2008.07.045

12. Cuzick J, Arbyn M, Sankaranarayanan R, Tsu V, Ronco G, Mayrand MH, et al. Overview of human papillomavirus based and other novel options for cervical cancer screening in developed and developing countries. Vaccine. 2008;26(Suppl 10):K29 41. doi:10.1016/j.vaccine.2008.06.019

13. Bravo Polanco E, Águila Rodríguez N, Guerra Villarpanda D, Blanco Vázquez Y, Rodríguez González O, Oliva Santana M. Cáncer cérvico uterino: prevención y tratamiento. Medisur. [Internet] 2020 [citado 24/11/2025];18(4). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1727-897X2020000400685

14. Akinyemiju TF. Socio economic and health access determinants of breast and cervical cancer screening in low income countries: analysis of the World Health Survey. PLoS One. 2012;7(11):e48834. doi:10.1371/journal.pone.0048834

15. Wang X, Ji Y, Liu J, Li X, Jiang J. Marital status and the risk of cervical cancer: a systematic review and meta analysis. Medicine (Baltimore). 2020;99(51):e23554. doi:10.1097/MD.0000000000023554

16. Matos Bisset A, Ali Pérez NA, Padrón Castillo M, Matos Bayeau AA, Cuevas Ramos B. Eficacia de la intervención educativa sobre el conocimiento del cáncer cérvicouterino. Acta Méd Centro [Internet]. 2019 [citado 24/11/2025];13(4):552-61. Disponible en: https://revactamedicacentro.sld.cu/index.php/amc/article/view/987

17. Díaz Brito Y, Báez Pupo MM, Pérez Rivero JL, García Placeres M. Presencia de algunos factores de riesgo de cáncer de cérvix en mujeres con citologías normales. Rev Cub Med Gen Integr. [Internet] 2014 [citado 24/11/2025];30(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-21252014000200005

18. Fernández Milán AM. Tabaquismo y su relación con otros factores de riesgo aterogénico en mujeres de edad mediana. Rev Cubana Med. [Internet] 2021 [citado 24/11/2025];60(2):1-9. Disponible en: https://www.medigraphic.com/pdfs/revcubmed/cm-2021/cm212f.pdf

19. Hecht SS, Hatsukami DK. Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention. Nat Rev Cancer. 2022;22(3):143-155. doi:10.1038/s41568-021-00423-4

20. Applebaum KM, Furniss CS, Zeka A, Posner MR, Smith JF, Bryan J, et al. Lack of association of alcohol and tobacco with HPV16 associated head and neck cancer. J Natl Cancer Inst. 2007;99(23):1801 10. doi:10.1093/jnci/djm234

21. Clarke MA, Devesa SS, Hammer A, Wentzensen N. Racial and Ethnic Differences in Hysterectomy-Corrected Uterine Corpus Cancer Mortality by Stage and Histologic Subtype. JAMA Oncol. 2022;8(6):895-903. doi:10.1001/jamaoncol.2022.0009

22. Gopalani SV, Sawaya GF, Rositch AF, et al. The impact of adjusting for hysterectomy prevalence on cervical cancer incidence rates and trends among women aged 30 years or older-United States, 2001-2019. Am J Epidemiol. 2024;193(8):1097-1105. doi:10.1093/aje/kwae041

23. Chacón Estrada L, Robert Brady Y, Martínez Casanova M. Desigualdades por condición racial en el complejo Osha-Ifá de Sagua la Grande. Ch [Internet]. 2024 [citado 24/11/2025];(25):176-95. Available from: https://chakinan.unach.edu.ec/index.php/chakinan/article/view/1161

24. Tamayo Lien TG, Varona Sánchez J, Borrego López J, Areces Delgado G. Relación colpohistológica en lesiones de cuello de alto grado. Rev Cubana Obstet Ginecol. [Internet] 2010 [citado 24/11/2025]; 36(3). Disponible en: http://scielo.sld.cu/pdf/gin/v36n3/gin12310.pdf

25. Hewavisenti RV, Arena J, Ahlenstiel CL, Sasson SC. Human papillomavirus in the setting of immunodeficiency: Pathogenesis and the emergence of next-generation therapies to reduce the high associated cancer risk. Front Immunol. 2023;14:1112513. doi:10.3389/fimmu.2023.1112513

26. Jensen KE, Schmiedel S, Frederiksen K, Norrild B, Iftner T, Kjær SK. Risk for cervical intraepithelial neoplasia grade 3 or worse in relation to parity among women with persistent human papillomavirus infection: a cohort study. Cancer Epidemiol Biomarkers Prev. 2012;21(11):1949 55. doi:10.1158/1055-9965.EPI-12-0434

27. Oyouni AAA. Human papillomavirus in cancer: Infection, disease transmission, and progress in vaccines. J Infect Public Health. 2023;16(4):626-631. doi:10.1016/j.jiph.2023.02.014

28. Nelson CW, Mirabello L. Human papillomavirus genomics: Understanding carcinogenicity. Tumour Virus Res. 2023;15:200258. doi:10.1016/j.tvr.2023.200258.

29. Harper DM, Navarro-Alonso JA, Bosch FX, et al. Impact of human papillomavirus vaccines in the reduction of infection, precursor lesions, and cervical cancer: A systematic literature review. Hum Vaccin Immunother. 2025;21(1):2497608. doi:10.1080/21645515.2025.2497608

30. Henschke N, Bergman H, Buckley BS, et al. Effects of human papillomavirus (HPV) vaccination programmes on community rates of HPV-related disease and harms from vaccination. Cochrane Database Syst Rev. 2025;11(11):CD015363. doi:10.1002/14651858.CD015363.pub2

Published

2026-08-21

How to Cite

1.
González-Díaz L, García-González S, González-Rodríguez G, Hernández-La Rosa A, Homma-Casto JL, Rendon-García S. Clinical characterization of patients with cervical cancer at the Provincial Gynecological-Obstetrical Hospital. Matanzas, 2023-2025. MedEst [Internet]. 2026 Aug. 21 [cited 2026 Sep. 22];6:e569. Available from: https://revmedest.sld.cu/index.php/medest/article/view/569

Issue

Section

RESEARCH ARTICLE