Anthracyclines: etiopathogenic basis of their cardiotoxicity
Keywords:
Anthracyclines, Cancer, Cardiotoxicity.Abstract
Cancer is a serious health problem of humanity, although there iscurrently an increase in expectations of a cure thanks to therapeutic
advances and they are anthracyclines are undoubtedly the most widely
prescribed cytotoxic agent despite their cardiotoxicity of 5% to 23% of
cases. The present literature review aimed toexplain the etiopathogenic
mechanisms of anthracyclines in the genesis of cardiotoxicity. For this, a
total of 22 bibliographic sources were consulted, including articles from
magazines, books and others, accessed through the main information
managers. It was concluded thatanthracycline-induced cardiotoxicity is
due to different mechanisms that are related to each other, these are the
production of free radicals, defects in mitochondrial structure and
function, alteration in calcium and iron homeostasis and alteration in gene
expression.
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References
Torres-Ajá L. Comportamiento del cáncer de mama en la provincia de Cienfuegos. Quinquenio 2007-2011. Revista Finlay 2013 [citado 12 de enero de 2020];3(3):[aprox.6p.]. Disponible en: http://www.revfinlay.sld.cu/index.php/finlay/article/view/141
Ruiz Mori E, Ayala Bustamante L, Burgos Bustamante J, Pacheco Román C. Cardiotoxicidad por quimioterapia en el Instituto Nacional de Enfermedades Neoplásicas 2012-2016. Horiz. Med. [Internet]. 2017 Jul [citado 13 de enero de 2020];17(3):24-28. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1727-558X2017000300005&lng=es
Souza CA, Simões R, Borges KBG, Oliveira AN, Zogeib JB, Alves BondLage A et al. Arterial Stiffness Use for Early Monitoring of Cardiovascular Adverse Events due to Anthracycline Chemotherapy in Breast Cancer Patients. A PilotStudy. Arq. Bras. Cardiol. [Internet]. 2018 Nov [citado 13 de enero de 2020];111(5):721-28. Disponible en: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018001700721&lng=en
Ministerio de Salud Pública. Dirección Nacional de Registros Médicos y Estadísticas de Salud. Anuario estadístico, 2018 [Internet]. Ministerio de Salud Pública; 2019 [citado 30 Enero de 2020]. Disponible en: https://salud.msp.gob.cu/tag/anuario-estadistico-de-salud/
Alert Silva J, Pérez Trejo M, Verdecia Cañizares C, FortezaSaez M, García Socarras D, del Castillo Bahi R. Cardiotoxicidad por irradiación en pediatría. RevCubanaPediatr. [Internet]. 2019 Sep [citado 13 de enero de 2020];91(3):e.893. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75312019000300008&lng=es
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